Vijg Lab Publications

2019

 

Zhang L* Dong X* Lee M, Maslov AY, Wang T, Vijg J. Single-cell whole-genome sequencing reveals the functional landscape of somatic mutations in B lymphocytes across the human lifespan. Proceedings of the National Academy of Sciences. 2019 April. 

https://www.pnas.org/content/116/18/9014

2018

 

Quispe-Tintaya, W., Lee, M., Dong, X., Weiser, D. A., Vijg, J. & Maslov, A. Bleomycin-induced genome structural variations in normal, non-tumor cells. Scientific reports. 2018 Dec 1. https://www.nature.com/articles/s41598-018-34580-8

 

Zhang, L. & Vijg, J. Somatic mutagenesis in mammals and its implications for human disease and aging. Annual Review of Genetics. 2018 Nov 23. https://www.annualreviews.org/doi/full/10.1146/annurev-genet-120417-031501

 

Niedernhofer, L. J., Gurkar, A. U., Wang, Y., Vijg, J., Hoeijmakers, J. H. J. & Robbins, P. D. Nuclear Genomic Instability and Aging. Scientific reports. Annual Review of Biochemistry. 2018 Jun 20. https://www.ncbi.nlm.nih.gov/pubmed/29925262

 

Dong, X., Shi, M., Lee, M., Toro, R., Gravina, S., Han, W., Yasuda, S., Wang, T.Zhang, Z.Vijg, J., Suh, Y. & Spivack, S. D.  Global, integrated analysis of methylomes and transcriptomes from laser capture microdissected bronchial and alveolar cells in human lung. Epigenetics. 2018 May 1. https://www.tandfonline.com/doi/abs/10.1080/15592294.2018.1441650

 

Hebert, J. M. & Vijg. Cell Replacement to Reverse Brain Aging: Challenges, Pitfalls, and Opportunities. Trends in Neurosciences. 2018 Jan 1. https://www.sciencedirect.com/science/article/pii/S0166223618300535

 

Maggi, E. C., Gravina, S., Cheng, H., Piperdi, B., Yuan, Z., Dong, X., Libutti, S. K., Vijg, J. & Montagna, C.Development of a method to implement whole-genome bisulfite sequencing of cfDNA from cancer patients and a mouse tumor model. Frontiers in Genetics. 2018 Jan 6. https://www.frontiersin.org/articles/10.3389/fgene.2018.00006/full

 


2017

 

Milholland, B., Suh, Y. & Vijg, J. Mutation and catastrophe in the aging genome. Experimental Gerontology. 2017 Aug. https://www.sciencedirect.com/science/article/pii/S0531556517301900

 

Le Bourg, E. & Vijg, J. The Future of Human Longevity: Time for a Reality Check. Gerontology. 2017 Aug 22. https://www.karger.com/Article/Abstract/478891

 

Vijg, J., Dong, X., Milholland, B. & Zhang, L. Genome instability: A conserved mechanism of ageingEssays in Biochemistry. 2017 Jul 11. http://essays.biochemistry.org/content/61/3/305.full

 

Vijg, J., Dong, X. & Zhang, L. A high-fidelity method for genomic sequencing of single somatic cells reveals a very high mutational burden. Experimental Biology and Medicine. 2017 Jul 1. https://journals.sagepub.com/doi/abs/10.1177/1535370217717696

 

Wiley, C. D., Flynn, J. M., Morrissey, C., Lebofsky, R., Shuga, J., Dong, X., Unger, M. A., Vijg, J., Melov, S. & Campisi. Analysis of individual cells identifies cell-to-cell variability following induction of cellular senescence. Aging Cell. 2017 Jul. https://onlinelibrary.wiley.com/doi/full/10.1111/acel.12632

 

Dong, X. & Vijg, J. Ageing: Biomarkers get physical. Nature Biomedical Engineering. 2017 Jun 30. https://www.nature.com/articles/s41551-017-0102

 

Milholland, B., Dong, X., Zhang, L., Hao, X., Suh, Y. & Vijg, J. Differences between germline and somatic mutation rates in humans and mice. Nature Communications. 2017 May 9. https://www.nature.com/articles/ncomms15183

 

Dong, X., Zhang, L., Milholland, B., Lee, M., Maslov, A., Wang, T. & Vijg, J. Accurate identification of single-nucleotide variants in whole-genome-amplified single cells. Nature Methods. 2017 Mar 20. https://www.nature.com/articles/nmeth.4227

 

Moskalev, A., Anisimov, V., Aliper, A., Artemov, A., Asadullah, K., Belsky, D., Baranova, A., de Grey, A., Dixit, V. D., Debonneuil, E., Dobrovolskaya, E., Fedichev, P., Fedintsev, A., Fraifeld, V., Franceschi, C., Freer, R., Fülöp, T., Feige, J., Gems, D., Gladyshev, V. & 50 others. A review of the biomedical innovations for healthy longevity. Aging. 2017 Jan. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5310653/

 

Miller, E. M., Patterson, N. E., Zechmeister, J. M., Bejerano-Development and validation of a targeted next generation DNA sequencing panel outperforming whole exome sequencing for the identification of clinically relevant genetic variants. Sagie, M., Delio, M., Patel, K., Ravi, N., Quispe-Tintaya, W., Maslov, A., Simmons, N., Castaldi, M., Vijg, J., Karabakhtsian, R. G., Greally, J. M., Kuo, D. Y-S. & Montagna, C. Oncotarget. 2017 Jan 1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731933/

 

Andriani, G. A., Vijg, J. & Montagna, C. Mechanisms and consequences of aneuploidy and chromosome instability in the aging brain. Mechanisms of Ageing and Development. 2017 Janhttps://www.sciencedirect.com/science/article/pii/S0047637416300288

 

Yu, B., Dong, X., Gravina, S., Kartal, Ö., Schimmel, T., Cohen, J., Tortoriello, D., Zody, R., Hawkins, R. D. & Vijg, J. Genome-wide, Single-Cell DNA Methylomics Reveals Increased Non-CpG Methylation during Human Oocyte Maturation. Stem Cell Reports. 2017 Jan 23. https://www.sciencedirect.com/science/article/pii/S2213671117302333

 


2016

 

Ozerov, I. V., Lezhnina, K. V., Izumchenko, E., Artemov, A. V., Medintsev, S., Vanhaelen, Q., Aliper, A., Vijg, J., Osipov, A. N., Labat, I., West, M. D., Buzdin, A., Cantor, C. R., Nikolsky, Y., Borisov, N., Irincheeva, I., Khokhlovich, E., Sidransky, D., Camargo, M. L. & Zhavoronkov, A. In silico Pathway Activation Network Decomposition Analysis (iPANDA) as a method for biomarker development. Nature Communications. 2016 Nov 16. https://www.nature.com/articles/ncomms13427

 

Dong, X., Milholland, B. & Vijg, J., 2016. Evidence for a limit to human lifespan. Nature. 2016 Oct 13. https://www.nature.com/articles/nature19793

 

Andriani, G. A., Almeida, V. P., Faggioli, F., Mauro, M., Li Tsai, W., Santambrogio, L., Maslov, A., Gadina, M., Campisi, J., Vijg, J. & Montagna, C. Whole chromosome instability induces senescence and promotes SASP. Scientific Reports. 2016 Oct 12. https://www.nature.com/articles/srep35218

 

White, R. R. & Vijg, J. Do DNA Double-Strand Breaks Drive Aging? Molecular Cell. 2016 Sep 1. https://www.sciencedirect.com/science/article/pii/S109727651630418X

 

Vermeij, W. P., Dollé, M. E. T., Reiling, E., Jaarsma, D., Payan-Gomez, C., Bombardieri, C. R., Wu, H., Roks, A. J. M., Botter, S. M., van der Eerden, B. C., Youssef, S. A., Kuiper, R. V., Nagarajah, B., van Oostrom, C. T., Brandt, R. M. C., Barnhoorn, S., Imholz, S., Pennings, J. L. A., de Bruin, A., Gyenis & 4 others. Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice. Nature. 2016 Aug 24. https://www.nature.com/articles/nature19329

 

Gravina, S., Dong, X., Yu, B. & Vijg, J. Single-cell genome-wide bisulfite sequencing uncovers extensive heterogeneity in the mouse liver methylome. Genome Biology. 2016 Jul 5. https://genomebiology.biomedcentral.com/articles/10.1186/s13059-016-1011-3

 

Zhang, Q., Nogales-Cadenas, R., Lin, J. R., Zhang, W., Cai, Y., Vijg, J. & Zhang, Z. Systems-level analysis of human aging genes shed new light on mechanisms of aging. Human Molecular Genetics. 2016 Jul 15. https://academic.oup.com/hmg/article/25/14/2934/2525770

 

Quispe-Tintaya, W., Gorbacheva, T., Lee, M., Makhortov, S., Popov, V. N., Vijg, J. & Maslov, A. Quantitative detection of low-abundance somatic structural variants in normal cells by high-throughput sequencing. Nature Methods. 2016 Jun 29. https://www.nature.com/articles/nmeth.3893

 

Putin, E., Mamoshina, P., Aliper, A., Korzinkin, M., Moskalev, A., Kolosov, A., Ostrovskiy, A., Cantor, C., Vijg, J. & Zhavoronkov, A. Deep biomarkers of human aging: Application of deep neural networks to biomarker development. Aging. 2016 May 18. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931851/

 

Patrick, A., Seluanov, M., Hwang, C., Tam, J., Khan, T., Morgenstern, A., Wiener, L., Vazquez, J. M., Zafar, H., Wen, R., Muratkalyeva, M., Doerig, K., Zagorulya, M., Cole, L., Catalano, S., Lobo Ladd, A. A. B., Coppi, A. A., Coskun, Y., Tian, X., Ablaeva, J. & 6 othersSensitivity of primary fibroblasts in culture to atmospheric oxygen does not correlate with species lifespan. Aging. 2016 May 7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931838/

 

The dark side of circulating nucleic acids.  Gravina, S., Sedivy, J. M. & Vijg, J.  Aging Cell. 2016 Feb 22. https://onlinelibrary.wiley.com/doi/full/10.1111/acel.12454

 

Andriani, G. A., Faggioli, F., Baker, D., Dollé, M. E. T., Sellers, R. S., Hebert, J. M., Van Steeg, H., Hoeijmakers, J., Vijg, J. & Montagna, C. Whole chromosome aneuploidy in the brain of Bub1bH/H and Ercc1-/Δ7 mice

. Human Molecular Genetics. 2016 Feb 15https://academic.oup.com/hmg/article/25/4/755/2384729

 


2015

 

White, R. R., Milholland, B., MacRae, S. L., Lin, M., Zheng, D. & Vijg, J. Comprehensive transcriptional landscape of aging mouse liver. BMC Genomics. 2015 Nov 5. https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-015-2061-8

 

Johnson, S. C., Dong, X., Vijg, J. & Suh, Y. Genetic evidence for common pathways in human age-related diseases. Aging Cell. 2015 Jun 15. https://onlinelibrary.wiley.com/doi/full/10.1111/acel.12362

 

Milholland, B., Auton, A., Suh, Y. & Vijg, J. Age-related somatic mutations in the cancer genome. Oncotarget. 2015 Sep 22. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694783/

 

Delio, M., Patel, K., Maslov, A., Marion, R. W., McDonald, T. V., Cadoff, E. M., Golden, A., Greally, J. M., Vijg, J., Morrow, B. E. & Montagna, C. Development of a targeted multi-disorder high-throughput sequencing assay for the effective identification of disease-causing variants. PLoS One. 2015 Jul 27. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0133742

 

White, R. R., Milholland, B., De Bruin, A., Curran, S., Laberge, R. M., Van Steeg, H., Campisi, J., Maslov, A. & Vijg, J. Controlled induction of DNA double-strand breaks in the mouse liver induces features of tissue ageing. Nature Communications. 2015 Apr 10. https://www.nature.com/articles/ncomms7790

 

Macrae, S. L., Zhang, Q., Lemetre, C., Seim, I., Calder, R. B., Hoeijmakers, J., Suh, Y., Gladyshev, V. N., Seluanov, A., Gorbunova, V., Vijg, J. & Zhang, Z. Comparative analysis of genome maintenance genes in naked mole rat, mouse, and human. Aging Cell. 2015 Jan 28. https://onlinelibrary.wiley.com/doi/full/10.1111/acel.12314

 

MacRae, S. L., Croken, M. M., Calder, R. B., Aliper, A., Milholland, B., White, R. R., Zhavoronkov, A., Gladyshev, V. N., Seluanov, A., Gorbunova, V., Zhang, Z. & Vijg, J. DNA repair in species with extreme lifespan differences. Aging.  2015 Dec 30. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712340/

 

Vijg, J. & Kennedy, B. K. The Essence of Aging. Gerontology. 2015 Sep 22. https://www.karger.com/Article/FullText/439348

 

Gravina, S., Ganapathi, S. & Vijg, J. Single-cell, locus-specific bisulfite sequencing (SLBS) for direct detection of epimutations in DNA methylation patterns. Nucleic Acids Research. 2015 Aug 18. https://academic.oup.com/nar/article/43/14/e93/2902662

 

Maslov, A., Quispe-Tintaya, W., Gorbacheva, T., White, R. R. & Vijg, J. High-throughput sequencing in mutation detection: A new generation of genotoxicity tests? Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 2015 Jun 1. https://www.sciencedirect.com/science/article/pii/S0027510715000913

 

Gorbacheva, T., Quispe-Tintaya, W., Popov, V. N., Vijg, J. & Maslov, A. Improved transposon-based library preparation for the ION Torrent platform. BioTechniques. 2015 Apr 3. https://www.future-science.com/doi/abs/10.2144/000114277

 

Longo, V. D., Antebi, A., Bartke, A., Barzilai, N., Brown-Borg, H. M., Caruso, C., Curiel, T. J., de Cabo, R., Franceschi, C., Gems, D., Ingram, D. K., Johnson, T. E., Kennedy, B. K., Kenyon, C., Klein, S., Kopchick, J. J., Lepperdinger, G., Madeo, F., Mirisola, M. G., Mitchell, J. R. & 10 others. Interventions to Slow Aging in Humans: Are We Ready? Aging Cell. 2015. https://onlinelibrary.wiley.com/doi/full/10.1111/acel.12338

 

Li, W., Calder, R. B., Mar, J. C. & Vijg, J. Single-cell transcriptogenomics reveals transcriptional exclusion of ENU-mutated alleles. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 2015 Feb 1. https://www.sciencedirect.com/science/article/pii/S0027510715000044

 

Tian, X., Azpurua, J., Ke, Z., Augereau, A., Zhang, Z., Vijg, J., Gladyshev, V. N., Gorbunova, V. & Seluanov, A. INK4 locus of the tumor-resistant rodent, the naked mole rat, expresses a functional p15/p16 hybrid isoform. Proceedings of the National Academy of Sciences of the United States of America. 2015 Jan 27. https://www.pnas.org/content/112/4/1053.short

 

Quispe-tintaya, W., White, R. R., Popov, V. N., Vijg, J. & Maslov, A. Rapid mitochondrial DNA isolation method for direct sequencing. Methods in molecular biology (Clifton, N.J.). 2015 Jan 6. https://link.springer.com/protocol/10.1007/978-1-4939-2257-4_9

 


2014

 

Demaria, M., Ohtani, N., Youssef, S., Rodier, F., Toussaint, W., Mitchell, J., Laberge, R. M., Vijg, J., VanSteeg, H., Dollé, M. T., Hoeijmakers, J. J., deBruin, A., Hara, E. & Campisi, J. An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA. Developmental Cell. 2014 Dec 22. https://www.sciencedirect.com/science/article/pii/S1534580714007291

 

Wessendorf, P., Vijg, J., Nussenzweig, A. & Digweed, M. Deficiency of the DNA repair protein nibrin increases the basal but not the radiation induced mutation frequency in vivo. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 2014 Nov. https://www.sciencedirect.com/science/article/pii/S0027510714001158

 

Furgason, J. M., Li, W., Milholland, B., Cross, E., Li, Y., McPherson, C. M., Warnick, R. E., Rixe, O., Stambrook, P. J., Vijg, J. & Bahassi, E. M. Whole genome sequencing of glioblastoma multiforme identifies multiple structural variations involved in EGFR activation. Mutagenesis. 2014 Sep. https://academic.oup.com/mutage/article/29/5/341/2763470

 

Gorbunova, V., Seluanov, A., Zhang, Z., Gladyshev, V. N. & Vijg, J. Comparative genetics of longevity and cancer: Insights from long-lived rodents.  Nature Reviews Genetics. 2014 Jul 1. https://www.nature.com/articles/nrg3728

 

McMurray, C. T. & Vijg, J. Editorial overview: Molecular and genetic bases of disease: the double life of DNA. Current Opinion in Genetics and Development. 2014 Jun 1. https://www.sciencedirect.com/science/article/pii/S0959437X14000975

 

Akman, K., Haaf, T., Gravina, S., Vijg, J. & Tresch, A. Genome-wide quantitative analysis of DNA methylation from bisulfite sequencing data. Bioinformatics. 2014 Jul 1. https://academic.oup.com/bioinformatics/article/30/13/1933/2422274

 

Vijg, J. Somatic mutations, genome mosaicism, cancer and aging. Current Opinion in Genetics and Development. 2014 Jun 1. https://www.sciencedirect.com/science/article/pii/S0959437X14000343

 

Reiling, E., Dollé, M. E. T., Youssef, S. A., Lee, M., Nagarajah, B., Roodbergen, M., De With, P., De Bruin, A., Hoeijmakers, J. H., Vijg, J., Van Steeg, H. & Hasty, P. The progeroid phenotype of Ku80 deficiency Is dominant over DNA-PK CS deficiency. PLoS One. 2014 Apr 16. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0093568

 

Vijg, J. Aging genomes: A necessary evil in the logic of life. BioEssays. 2014 Mar. https://onlinelibrary.wiley.com/doi/full/10.1002/bies.201300127

 

Faggioli, F., Vijg, J. & Montagna, C. Four-color FISH for the detection of low-level aneuploidy in interphase cells. Methods in molecular biology (Clifton, N.J.). 2014 Feb. https://www.ncbi.nlm.nih.gov/pubmed/24633803

 

Choi, Y. J., Li, H., Son, M. Y., Wang, X. H., Fornsaglio, J. L., Sobol, R. W., Lee, M., Vijg, J., Imholz, S., Dollé, M. E. T., Van Steeg, H., Reiling, E. & Hasty, P. Deletion of individual Ku subunits in mice causes an NHEJ-independent phenotype potentially by altering apurinic/apyrimidinic site repair. PLoS One. 2014 Jan 23. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0086358

 

Vijg, J. & De Grey, A. D. N. J. Innovating aging: Promises and pitfalls on the road to life extension. Gerontology. 2014. https://www.karger.com/Article/FullText/357670

 


2013

 

Melis, J. P. M., Jonker, M. J., Vijg, J., Hoeijmakers, J. H. J., Breit, T. M. & van Steeg, H. Aging on a different scale - chronological versus pathology-related aging. Aging. 2013 Oct 16. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3838780/

 

Jonker, M. J., Melis, J. P. M., Kuiper, R. V., van der Hoeven, T. V., Wackers, P. F. K., Robinson, J., van der Horst, G. T. J., Dollé, M. E. T., Vijg, J., Breit, T. M., Hoeijmakers, J. H. J. & Van Steeg, H. Life spanning murine gene expression profiles in relation to chronological and pathological aging in multiple organs. Aging Cell. 2013 Oct. https://onlinelibrary.wiley.com/doi/full/10.1111/acel.12118

 

Gravina, S., Dollé, M. E. T., Wang, T., van Steeg, H., Hasty, P., Hoeijmakers, J. & Vijg, J. High Preservation of CpG Cytosine Methylation Patterns at Imprinted Gene Loci in Liver and Brain of Aged Mice. PLoS One. 2013 Sep 9. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0073496

 

Greer, C., Lee, M., Westerhof, M., Milholland, B., Spokony, R., Vijg, J. & Secombe, J. Myc-Dependent Genome Instability and Lifespan in Drosophila. PLoS One. 2013 Sep 6. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0074641

 

Quispe-Tintaya, W., White, R. R., Popov, V. N., Vijg, J. & Maslov, A. Fast mitochondrial DNA isolation from mammalian cells for next-generation sequencing. BioTechniques. 2013 Sep. https://www.future-science.com/doi/full/10.2144/000114077

 

Maslov, A., Ganapathi, S., Westerhof, M., Quispe-Tintaya, W., White, R. R., Van Houten, B., Reiling, E., Dollé, M. E. T., van Steeg, H., Hasty, P., Hoeijmakers, J. H. J. & Vijg, J. DNA damage in normally and prematurely aged mice. Aging Cell. 2013 Jun. https://onlinelibrary.wiley.com/doi/full/10.1111/acel.12071

 

Garagnani, P., Giuliani, C., Pirazzini, C., Olivieri, F., Bacalini, M. G., Ostan, R., Mari, D., Passarino, G., Monti, D., Bonfigli, A. R., Boemi, M., Ceriello, A., Genovese, S., Sevini, F., Luiselli, D., Tieri, P., Capri, M., Salvioli, S., Vijg, J., Suh, Y. & 3 others. Centenarians as super-controls to assess the biological relevance of genetic risk factors for common age-related diseases: A proof of principle on type 2 diabetes. Aging. 2013 May 31. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701112/


Beltrami, E., Ruggiero, A., Busuttil, R., Migliaccio, E., Pelicci, P. G., Vijg, J. & Giorgio, M. Deletion of p66shc in mice increases the frequency of size-change mutations in the lacZ transgene. Aging Cell. 2013 Apr. https://onlinelibrary.wiley.com/doi/full/10.1111/acel.12036

Vijg, J. & Suh, Y. Genome instability and aging. Annual Review of Physiology. 2013 Feb 10. https://www.annualreviews.org/doi/full/10.1146/annurev-physiol-030212-183715?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed

 


2012

 

Maslov, A., Lee, M., Gundry, M., Gravina, S., Strogonova, N., Tazearslan, C., Bendebury, A., Suh, Y. & Vijg, J. 5-Aza-2′-deoxycytidine-induced genome rearrangements are mediated by DNMT1. Oncogene. 2012 Dec 13. https://www.nature.com/articles/onc20129


Faggioli, F., Wang, T., Vijg, J. & Montagna, C. Chromosome-specific accumulation of aneuploidy in the aging mouse brain. Human Molecular Genetics. 2012 Dec. https://academic.oup.com/hmg/article/21/24/5246/664964


Kim, T. M., Ko, J. H., Hu, L., Kim, S. A., Bishop, A. J. R., Vijg, J., Montagna, C. & Hasty, P. RAD51 mutants cause replication defects and chromosomal instability. Molecular and Cellular Biology. 2012 Sep. https://mcb.asm.org/content/32/18/3663.short


Gombar, S., Jung, H. J., Dong, F., Calder, B., Atzmon, G., Barzilai, N., Tian, X. L., Pothof, J., Hoeijmakers, J. H. J., Campisi, J., Vijg, J. & Suh, Y. Comprehensive microRNA profiling in B-cells of human centenarians by massively parallel sequencing. BMC Genomics. 2012 Jul 31. https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-13-353

 

Anisimov, V. N., Bartke, A., Barzilai, N., Batin, M. A., Blagosklonny, M. V., Brown-Borg, H., Budovskaya, Y., Campisi, J., Friguet, B., Fraifeld, V., Franceschi, C., Gems, D., Gladyshev, V., Gorbunova, V., Gudkov, A. V., Kennedy, B., Konovalenko, M., Kraemer, B., Moskalev, A., Petropoulos, I. & 10 others. The second international conference "genetics of aging and longevity". Aging. 2012 May. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5533612/


Gundry, M., Li, W., Maqbool, S. B. & Vijg, J. Direct, genome-wide assessment of DNA mutations in single cells. Nucleic Acids Research. 2012 Mar. https://academic.oup.com/nar/article/40/5/2032/1109685 

 

Li, W. & Vijg, J. Measuring genome instability in aging - A mini-review. Gerontology. 2012 Feb. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696364/


Gundry, M. & Vijg, J. Direct mutation analysis by high-throughput sequencing: From germline to low-abundant, somatic variants. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 2012 Jan 3. https://www.sciencedirect.com/science/article/pii/S0027510711002661

 


2011

 

Garcia, A. M., Salomon, R. N., Witsell, A., Liepkalns, J., Calder, R. B., Lee, M., Lundell, M., Vijg, J. & McVey, M. Loss of the bloom syndrome helicase increases DNA ligase 4-independent genome rearrangements and tumorigenesis in aging Drosophila. Genome Biology. 2011 Dec 19. https://genomebiology.biomedcentral.com/articles/10.1186/gb-2011-12-12-r121


Faggioli, F., Vijg, J. & Montagna, C. Chromosomal aneuploidy in the aging brain. Mechanisms of Ageing and Development. 2011 Aug. https://www.sciencedirect.com/science/article/pii/S0047637411000534

 


2010

 

Vijg, J. Interview with Jan Vijg, Ph.D. [Interviewed by Vicki Glaser]. Rejuvenation Research. 2010 Oct. http://go.galegroup.com/ps/anonymous?id=GALE%7CA245302535&sid=googleScholar&v=2.1&it=r&linkaccess=abs&issn=15491684&p=AONE&sw=w

 

Suh, Y. & Vijg, J. The long and short of fertility and longevity. Cell Metabolism. 2010 Sep 8. https://www.sciencedirect.com/science/article/pii/S1550413110002779?via%3Dihub


Rae, M. J., Butler, R. N., Campisi, J., De Grey, A. D. N. J., Finch, C. E., Gough, M., Martin, G. M., Vijg, J., Perrott, K. M. & Logan, B. J. The demographic and biomedical case for late-life interventions in aging. Science Translational Medicine. 2010 Jul 14. http://stm.sciencemag.org/content/2/40/40cm21.short


Vijg, J. Aging of the Genome: The dual role of DNA in life and death. Oxford University Press. 2010 Apr . http://www.oxfordscholarship.com/view/10.1093/acprof:oso/9780198569237.001.0001/acprof-9780198569237

 

Blagosklonny, M. V., Campisi, J., Sinclair, D. A., Bartke, A., Blasco, M. A., Bonner, W. M., Bohr, V. A., Brosh, R. M., Brunet, A., DePinho, R. A., Donehower, L. A., Finch, C. E., Finkel, T., Gorospe, M., Gudkov, A. V., Hall, M. N., Hekimi, S., Helfand, S. L., Karlseder, J., Kenyon, C. & 15 others. Impact papers on aging in 2009. Aging. 2010 Mar. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871240/


Gravina, S. & Vijg, J. Epigenetic factors in aging and longevity. Pflugers Archiv European Journal of Physiology. Jan 2010. 

Garcia, A. M., Calder, R. B., Dollé, M. E. T., Lundell, M., Kapahi, P. & Vijg, J. Age- and temperature-dependent somatic mutation accumulation in Drosophila melanogaster. PLoS Genetics. 2010. https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1000950

 


2009

 

Kapahi, P. & Vijg, J. Aging - Lost in translation? New England Journal of Medicine. 2009 Dec 31. https://www.nejm.org/doi/full/10.1056/NEJMcibr0909815

 

Maslov, A., Metrikin, M. & Vijg, J. A dual-activation, adenoviral-based system for the controlled induction of DNA double-strand breaks by the restriction endonuclease SacI. BioTechniques. 2009 Oct. https://www.future-science.com/doi/abs/10.2144/000113237

 

Maslov, A. & Vijg, J. Genome instability, cancer and aging.  Biochimica et Biophysica Acta - General Subjects. 2009 Oct. https://www.sciencedirect.com/science/article/pii/S0304416509000749

 

Edman, U., Garcia, A. M., Busuttil, R. A., Sorensen, D., Lundell, M., Kapahi, P. & Vijg, J. Lifespan extension by dietary restriction is not linked to protection against somatic DNA damage in Drosophila melanogaster. Aging Cell. 2009 Jun. https://onlinelibrary.wiley.com/doi/full/10.1111/j.1474-9726.2009.00480.x

 

Vijg, J. SNP'ing for longevity. Aging. 2009 May. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806028/

 

Campisi, J. & Vijg, J. Does damage to DNA and other macromolecules play a role in aging? If so, how? Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2009 Feb. https://academic.oup.com/biomedgerontology/article/64A/2/175/665362

 

Khrapko, K. & Vijg, J. Mitochondrial DNA mutations and aging: devils in the details? Trends in Genetics. 2009 Feb. https://www.sciencedirect.com/science/article/pii/S0168952508003168

 

Pérez, V. I., Van Remmen, H., Bokov, A., Epstein, C. J., Vijg, J. & Richardson, A. The overexpression of major antioxidant enzymes does not extend the lifespan of mice. Aging Cell. 2009 Jan. https://onlinelibrary.wiley.com/doi/full/10.1111/j.1474-9726.2008.00449.x

 

Geiger, H., David, S., Nattamai, K. J. & Vijg, J. Quantification of genomic mutations in murine hematopoietic cells. Methods in molecular biology (Clifton, N.J.). 2009. https://link.springer.com/protocol/10.1007/978-1-59745-409-4_28
 


2008

 

Vijg, J., Maslov, A. & Suh, Y. Aging: A Sirtuin Shake-Up? Cell. Nov 28 2008. https://www.sciencedirect.com/science/article/pii/S0092867408014372

Wang, G., Carbajal, S., Vijg, J., DiGiovanni, J. & Vasquez, K. M. DNA structure-induced genomic instability in vivo. Journal of the National Cancer Institute. 2008 Dec 17. https://academic.oup.com/jnci/article/100/24/1815/2606903

 

Holcomb, V. B., Rodier, F., Choi, Y., Busuttil, R. A., Vogel, H., Vijg, J., Campisi, J. & Hasty, P. Ku80 deletion suppresses spontaneous tumors and induces a p53-mediated DNA damage response. Cancer Research. 2008 Nov 15. http://cancerres.aacrjournals.org/content/68/22/9497.short

 

Garinis, G. A., van der Horst, G. T. J., Vijg, J. & Hoeijmakers, J. H. J. DNA damage and ageing: New-age ideas for an age-old problem. Nature Cell Biology. 2008 Nov 1. https://www.nature.com/articles/ncb1108-1241

 

Longo, V. D., Lieber, M. R. & Vijg, J. Turning anti-ageing genes against cancer. Nature Reviews Molecular Cell Biology. 2008 Nov . https://www.nature.com/articles/nrm2526

 

Busuttil, R. A., Muñoz, D. P., Garcia, A. M., Rodier, F., Kim, W. H., Suh, Y., Hasty, P., Campisi, J. & Vijg, J. Effect of Ku80 deficiency on mutation frequencies and spectra at a lacZ reporter locus in mouse tissues and cells. PLoS One. 2008 Oct 20. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0003458

 

Garcia, A. M., Busuttil, R. A., Calder, R. B., Dollé, M. E. T., Diaz, V., McMahan, C. A., Bartke, A., Nelson, J., Reddick, R. & Vijg, J. Effect of Ames dwarfism and caloric restriction on spontaneous DNA mutation frequency in different mouse tissues. Mechanisms of Ageing and Development. 2008 Sep. https://www.sciencedirect.com/science/article/pii/S0047637408001048

 

Vijg, J. & Campisi, J. Puzzles, promises and a cure for ageing. Nature. 2008 Aug 28. https://www.nature.com/articles/nature07216

 

Ouchida, R., Ukai, A., Mori, H., Kawamura, K., Dollé, M. E. T., Tagawa, M., Sakamoto, A., Tokuhisa, T., Yokosuka, T., Saito, T., Yokoi, M., Hanaoka, F., Vijg, J. & Wang, J. Y. Genetic analysis reveals an intrinsic property of the germinal center B cells to generate A: T mutations. DNA Repair. 2008 Aug 2. https://www.sciencedirect.com/science/article/pii/S1568786408001687

 

Vijg, J. The role of DNA damage and repair in aging: New approaches to an old problem. Mechanisms of Ageing and Development. Jul 2008. https://www.sciencedirect.com/science/article/pii/S0047637408000511

 

Park, J. Y., Cho, M. O., Leonard, S., Calder, B., Mian, I. S., Kim, W. H., Wijnhoven, S., van Steeg, H., Mitchell, J., van der Horst, G. T. J., Hoeijmakers, J., Cohen, P., Vijg, J. & Suh, Y. Homeostatic imbalance between apoptosis and cell renewal in the liver of premature aging XpdTTD mice. PLoS One. 2008 Jun 11. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0002346

 

Busuttil, R. A., Lin, Q., Stambrook, P. J., Kucherlapati, R. & Vijg, J. Mutation frequencies and spectra in DNA polymerase η-deficient mice. Cancer Research. 2008 Apr 1. http://cancerres.aacrjournals.org/content/68/7/2081.short

 

Melis, J. P. M., Wijnhoven, S. W. P., Beems, R. B., Roodbergen, M., Van Den Berg, J., Moon, H., Friedberg, E., Van Der Horst, G. T. J., Hoeijmakers, J. H. J., Vijg, J. & Van Steeg, H. Mouse models for xeroderma pigmentosum group A and group C show divergent cancer phenotypes. Cancer Research. 2008 Mar 1. http://cancerres.aacrjournals.org/content/68/5/1347.short

 


2007

 

Busuttil, R. A., Garcia, A. M., Reddick, R. L., Dollé, M. E. T., Calder, R. B., Nelson, J. E. & Vijg, J. Intra-organ variation in age-related mutation accumulation in the mouse. PLoS One. 2007 Sep 12. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0000876

 

Vijg, J. & Dollé, M. E. T. Genome instability: Cancer or aging? Mechanisms of Ageing and Development. 2007 Jul. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2679218/

 

Vijg, J. & Bohr, V. A. Preface. Mechanisms of Ageing and Development. 2007 Jul. https://www.sciencedirect.com/science/article/pii/S0047637407000668?via%3Dihub

 

Calder, R. B., Beems, R. B., van Steeg, H., Mian, I. S., Lohman, P. H. M. & Vijg, J. MPHASYS: A mouse phenotype analysis system. BMC Bioinformatics. 2007 Jun 6. https://bmcbioinformatics.biomedcentral.com/articles/10.1186/1471-2105-8-183

 

Garcia, A. M., Derventzi, A., Busuttil, R., Calder, R. B., Perez, E., Chadwell, L., Dollé, M. E. T., Lundell, M. & Vijg, J. A model system for analyzing somatic mutations in Drosophila melanogaster. Nature Methods. 2007 May. https://www.nature.com/articles/nmeth1027

 

Busuttil, R., Bahar, R. & Vijg, J. Genome dynamics and transcriptional deregulation in aging. Neuroscience. 2007 Apr 14. https://www.sciencedirect.com/science/article/pii/S0306452206012899

 

Garcia, A. M., Busuttil, R. A., Rodriguez, A., Cabrera, C., Lundell, M., Dolle, M. E. T. & Vijg, J. Detection and analysis of somatic mutations at a lacZ reporter locus in higher organisms: Application to Mus musculus and Drosophila melanogaster. Methods in Molecular Biology. 2007 Apr 5. https://link.springer.com/protocol/10.1007%2F978-1-59745-361-5_20

 

Khrapko, K. & Vijg, J. Mitochondrial DNA mutations and aging: A case closed? Nature Genetics. 2007 Apr. https://www.nature.com/articles/ng0407-445

 

Vijg, J. & Suh, Y. Third International Conference on Functional Genomics of Ageing, March 29-April 1 2006, Palermo, Sicily, Italy.  Mechanisms of Ageing and Development. 2007 Jan. https://www.sciencedirect.com/science/article/pii/S004763740600234X?via%3Dihub
 


2006

 

Niedernhofer, L. J., Garinis, G. A., Raams, A., Lalai, A. S., Robinson, A. R., Appeldoorn, E., Odijk, H., Oostendorp, R., Ahmad, A., Van Leeuwen, W., Theil, A. F., Vermeulen, W., Van Der Horst, G. T. J., Meinecke, P., Kleijer, W. J., Vijg, J., Jaspers, N. G. J. & Hoeijmakers, J. H. J. A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis. Nature. 2006 Dec 21 https://www.nature.com/articles/nature05456

 

Cabelof, D. C., Ikeno, Y., Nyska, A., Busuttil, R. A., Anyangwe, N., Vijg, J., Matherly, L. H., Tucker, J. D., Wilson, S. H., Richardson, A. & Heydari, A. R. Haploinsufficiency in DNA polymerase β increases cancer risk with age and alters mortality rate. Cancer Research. 2006 Aug 1. http://cancerres.aacrjournals.org/content/66/15/7460.short

 

Bahar, R., Hartmann, C. H., Rodriguez, K. A., Denny, A. D., Busuttil, R. A., Dollé, M. E. T., Calder, R. B., Chisholm, G. B., Pollock, B. H., Klein, C. A. & Vijg, J. Increased cell-to-cell variation in gene expression in ageing mouse heart. Nature. 2006 Jun 22. https://www.nature.com/articles/nature04844

 

Khrapko, K., Kraytsberg, Y., de Grey, A. D. N. J., Vijg, J. & Schon, E. A. Does premature aging of the mtDNA mutator mouse prove that mtDNA mutations are involved in natural aging? Aging Cell. 2006 Jun. https://onlinelibrary.wiley.com/doi/full/10.1111/j.1474-9726.2006.00209.x

 

Finkel, T., Vijg, J. & Shay, J. W. Time, tumours and telomeres: Meeting on cancer and aging. EMBO Reports. 2006 May. http://embor.embopress.org/content/7/5/479.abstract

 

Vijg, J. & Suh, Y. Ageing: Chromatin unbound. Nature. 2006 Apr 13. https://www.nature.com/articles/440874a

 

Dollé, M. E. T., Busuttil, R. A., Garcia, A. M., Wijnhoven, S., van Drunen, E., Niedernhofer, L. J., van der Horst, G., Hoeijmakers, J. H. J., van Steeg, H. & Vijg, J. Increased genomic instability is not a prerequisite for shortened lifespan in DNA repair deficient mice. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 2006 Apr 11. https://www.sciencedirect.com/science/article/pii/S0027510705005324

 

Mele, J., Van Remmen, H., Vijg, J. & Richardson, A. Characterization of transgenic mice that overexpress both copper zinc superoxide dismutase and catalase. Antioxidants and Redox Signaling. 2006 Mar. https://www.liebertpub.com/doi/abs/10.1089/ars.2006.8.628

 

Suh, Y. & Vijg, J. Maintaining genetic integrity in aging: A zero sum game. Antioxidants and Redox Signaling. 2006 Mar. https://www.liebertpub.com/doi/abs/10.1089/ars.2006.8.559

 

Busuttil, R. A., Rubio, M., Dollé, M. E. T., Campisi, J. & Vijg, J. Mutant frequencies and spectra depend on growth state and passage number in cells cultured from transgenic lacZ-plasmid reporter mice. DNA Repair. 2006 Jan 5. https://www.sciencedirect.com/science/article/pii/S1568786405001977

 

 


2005

 

Busuttil, R. A., Garcia, A. M., Cabrera, C., Rodriguez, A., Suh, Y., Kim, W. H., Huang, T. T. & Vijg, J. Organ-specific increase in mutation accumulation and apoptosis rate in CuZn-superoxide dismutase-deficient mice. Cancer Research. 200 Dec 15. http://cancerres.aacrjournals.org/content/65/24/11271.short

 

Vijg, J. & Hasty, P. Aging and p53: Getting it straight A commentary on a recent paper by Gentry and Venkatachalam. Aging Cell. 2005 Dec. https://onlinelibrary.wiley.com/doi/full/10.1111/j.1474-9726.2005.00179.x

 

Wijnhoven, S. W. P., Beems, R. B., Roodbergen, M., Van Den Berg, J., Lohman, P. H. M., Diderich, K., Van Der Horst, G. T. J., Vijg, J., Hoeijmakers, J. H. J. & Van Steeg, H. Accelerated aging pathology in ad libitum fed XpdTTD mice is accompanied by features suggestive of caloric restriction. DNA Repair. 2005 Nov 21. https://www.sciencedirect.com/science/article/pii/S1568786405001928

 

Leroi, A. M., Bartke, A., De Benedictis, G., Franceschi, C., Gartner, A., Gonos, E. S., Fedei, M. E., Kivisild, T., Lee, S., Kartaf-Ozer, N., Schumacher, M., Sikora, E., Slagboom, E., Tatar, M., Yashin, A. I., Vijg, J. & Zwaan, B. What evidence is there for the existence of individual genes with antagonistic pleiotropic effects? Mechanisms of Ageing and Development. 2005 Aug. https://www.sciencedirect.com/science/article/pii/S0047637404001897

 

Suh, Y. & Vijg, J. SNP discovery in associating genetic variation with human disease phenotypes. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 2005 Jun 3. https://www.sciencedirect.com/science/article/pii/S0027510705000254

 

McCammon, M. T., Gillette, J. S., Thomas, D. P., Ramaswamy, S. V., Rosas, I. I., Graviss, E. A., Vijg, J. & Quitugua, T. N. Detection by denaturing gradient gel electrophoresis of pncA mutations associated with pyrazinamide resistance in Mycobacterium tuberculosis isolates from the United States-Mexico border region. Antimicrobial Agents and Chemotherapy. 2005 Jun. https://aac.asm.org/content/49/6/2210.full

 

McCammon, M. T., Gillette, J. S., Thomas, D. P., Ramaswamy, S. V., Graviss, E. A., Kreiswirth, B. N., Vijg, J. & Quitugua, T. N. Detection of rpoB mutations associated with rifampin resistance in Mycobacterium tuberculosis using denaturing gradient gel electrophoresis. Antimicrobial Agents and Chemotherapy. 2005 Jun. https://aac.asm.org/content/49/6/2200.full

 

Leroi, A. M., Bartke, A., Benedictis, G. D., Franceschi, C., Gartner, A., Gonos, E., Feder, M. E., Kivisild, T., Lee, S., Kartal-Özer, N., Schumacher, M., Sikora, E., Slagboom, E., Tatar, M., Yashin, A. I., Vijg, J. & Zwaan, B. What evidence is there for the existence of individual genes with antagonistic pleiotropic effects? Mechanisms of Ageing and Development. 2005 Mar. https://www.sciencedirect.com/science/article/pii/S0047637404001897

 

Vijg, J. & Suh, Y. Second international conference on Functional Genomics of Ageing, April 28-May 1 2004, Hersonissos, Crete, Greece. Mechanisms of Ageing and Development. 2005 Jan. https://doi.org/10.1016/j.mad.2004.09.018

 

Vijg, J., Busuttil, R. A., Bahar, R. & Dollé, M. E. T. Aging and genome maintenance. Annals of the New York Academy of Sciences. 2005. https://nyaspubs.onlinelibrary.wiley.com/doi/full/10.1196/annals.1323.007

 

Vijg, J. & Suh, Y. Genetics of longevity and aging. Annual Review of Medicine. 2005. https://www.annualreviews.org/doi/full/10.1146/annurev.med.56.082103.104617

 


2004

 

Vijg, J. Impact of genome instability on transcription regulation of aging and senescence. Mechanisms of Ageing and Development. 2004 Oct. https://www.sciencedirect.com/science/article/pii/S0047637404001654

 

Vijg, J. & Calder, R. B. Transcripts of aging.  Trends in Genetics. 2004 Jun 1. https://www.sciencedirect.com/science/article/pii/S0168952504001003

 

Hasty, P. & Vijg, J. Accelerating aging by mouse reverse genetics: A rational approach to understanding longevity. Aging Cell. 2004 Apr. https://onlinelibrary.wiley.com/doi/full/10.1111/j.1474-9728.2004.00082.x

 

Hasty, P. & Vijg, J. Rebuttal to Miller: 'Accelerated aging': A primrose path to insight?' Aging Cell. 2004 Apr. https://onlinelibrary.wiley.com/doi/full/10.1111/j.1474-9728.2004.00087.x

 

Chen, X., Liang, H., Van Remmen, H., Vijg, J. & Richardson, A. Catalase transgenic mice: Characterization and sensitivity to oxidative stress. Archives of Biochemistry and Biophysics. 2004 Feb 15. https://www.sciencedirect.com/science/article/pii/S0003986103007008

 

Busuttil, R. A., Dollé, M., Campisi, J. & Vijg, J. Genomic instability, aging, and cellular senescence. Annals of the New York Academy of Sciences. 2004. https://nyaspubs.onlinelibrary.wiley.com/doi/full/10.1196/annals.1297.041

 


2003

 

Busuttil, R. A., Rubio, M., Dollé, M. E. T., Campisi, J. & Vijg, J. Oxygen accelerates the accumulation of mutations during the senescence and immortalization of murine cells in culture. Aging Cell. 2003 Dec. https://onlinelibrary.wiley.com/doi/full/10.1046/j.1474-9728.2003.00066.x

 

Yang, H., Shi, M., Richardson, A., Vijg, J. & Guo, Z. Attenuation of leukocyte-endothelium interaction by antioxidant enzymes. Free Radical Biology and Medicine. 2003 Aug 1. https://www.sciencedirect.com/science/article/pii/S0891584903002776

 

Bounpheng, M., McGrath, S., Macias, D., van Orsouw, N., Suh, Y., Rines, D. & Vijg, J. Rapid, inexpensive scanning for all possible BRCA1 and BRCA2 gene sequence variants in a single assay: implications for genetic testing. Journal of Medical Genetics. 2003 Apr. https://jmg.bmj.com/content/40/4/e33


Hoogervorst, E. M., de Vries, A., Beems, R. B., van Oostrom, C. T. M., Wester, P. W., Vos, J. G., Bruins, W., Roodbergen, M., Cassee, F. R., Vijg, J., van Schooten, F. J. & van Steeg, H. Combined oral benzo[a]pyrene and inhalatory ozone exposure have no effect on lung tumor development in DNA repair-deficient Xpa mice. Carcinogenesis. 2003 Mar 1. https://academic.oup.com/carcin/article/24/3/613/2608456


Hasty, P., Campisi, J., Hoeijmakers, J., Van Steeg, H. & Vijg, J. Aging and genome maintenance: Lessons from the mouse? Science. 2003 Feb 28. http://science.sciencemag.org/content/299/5611/1355

 

Chen, X., Mele, J., Giese, H., Van Remmen, H., Dollé, M. E. T., Steinhelper, M., Richardson, A. & Vijg, J. A strategy for the ubiquitous overexpression of human catalase and CuZn superoxide dismutase genes in transgenic mice. Mechanisms of Ageing and Development. 2003 Feb 1. https://www.sciencedirect.com/science/article/pii/S0047637402001616

 

Yang, H., Shi, M., VanRemmen, H., Chen, X., Vijg, J., Richardson, A. & Guo, Z. Reduction of pressor response to vasoconstrictor agents by overexpression of catalase in mice. American Journal of Hypertension. 2003 Jan 1. https://academic.oup.com/ajh/article/16/1/1/111051

 

Vijg, J. & Suh, Y. Screening for mutations in cancer-predisposition genes. Genetic Predisposition to Cancer, Second Edition. CRC Press. 2003 Jan 1. https://einstein.pure.elsevier.com/en/publications/screening-for-mutations-in-cancer-predisposition-genes

 

Vijg, J. & Suh, Y. Special issue - International conference on 'Functional Genomics of Ageing', April 24-27, 2002, Seville, SpainMechanisms of Ageing and Development. 2003 Jan. https://www.researchgate.net/publication/263558481_Special_Issue-International_Conference_on_'Functional_Genomics_of_Ageing'_April_24-27_2002_Seville_Spain

 

Vijg, J. & Suh, Y. Functional genomics of ageing. Mechanisms of Ageing and Development. 2003 Jan. https://www.sciencedirect.com/science/article/pii/S004763740200163X

 


2002

 

Dollé, M. E. T. & Vijg, J.Genome dynamics in aging miceGenome Research. 2002 Nov 1. https://genome.cshlp.org/content/12/11/1732

 

Hasty, P. & Vijg, J. Genomic priorities in aging. Science. 2002 May 17. http://science.sciencemag.org/content/296/5571/1250

 

Vijg, J. & Dollé, M. E. T. Large genome rearrangements as a primary cause of aging. Mechanisms of Ageing and Development. 2002 Apr 30. https://www.sciencedirect.com/science/article/pii/S0047637402000283

 

Vijg, J. Preface to 'Time, Cells, and Strehler'. Mechanisms of Ageing and Development. 2002 Apr 30. https://www.researchgate.net/publication/279794623_Preface_to_'Time_cells_and_Strehler'_-_Preface

 

Nekhaeva, E., Bodyak, N. D., Kraytsberg, Y., McGrath, S. B., Van Orsouw, N. J., Pluzhnikov, A., Wei, J. Y., Vijg, J. & Khrapko, K. Clonally expanded mtDNA point mutations are abundant in individual cells of human tissues. Proceedings of the National Academy of Sciences of the United States of America. 2002 Apr 16. https://www.pnas.org/content/99/8/5521.short

 

Vijg, J. On key lesions and all that: A tribute to Paul Lohman. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 2002 Feb 20. https://www.sciencedirect.com/science/article/pii/S0027510701003025

 

Giese, H., Snyder, W. K., Van Oostrom, C., Van Steeg, H., Dollé, M. E. T. & Vijg, J. Age-related mutation accumulation at a lacZ reporter locus in normal and tumor tissues of Trp53-deficient mice. Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 2002 Feb 15. https://www.sciencedirect.com/science/article/pii/S1383571801003291

 

Dollé, M. E. T., Snyder, W. K., Dunson, D. B. & Vijg, J. Mutational fingerprints of aging. Nucleic Acids Research. 2002 Jan 15. https://academic.oup.com/nar/article/30/2/545/2380437

 

Vijg, J. & Van Orsouw, N.Searching for genetic determinants of human aging and longevity: Opportunities and challenges. Mechanisms of Ageing and Development. 2002. https://www.sciencedirect.com/science/article/pii/S0047637401003463

 

Suh, Y., Lee, K. A., Kim, W. H., Han, B. G., Vijg, J. & Park, S. C. Aging alters the apoptotic response to genotoxic stress. Nature Medicine. 2002. https://www.nature.com/articles/nm0102-3

 

Andrulis, I. L., Anton-Culver, H., Beck, J., Bove, B., Boyd, J., Buys, S., Godwin, A. K., Hopper, J. L., Li, F., Neuhausen, S. L., Ozcelik, H., Peel, D., Santella, R. M., Southey, M. C., Van Orsouw, N. J., Venter, D. J., Vijg, J. & Whittemore, A. S. Comparison of DNA- and RNA-based methods for detection of truncating BRCA1 mutations. Human Mutation. 2002. https://onlinelibrary.wiley.com/doi/abs/10.1002/humu.10097

 


2001

 

McGrath, S. B., Bounpheng, M., Torres, L., Calavetta, M., Scott, C. B., Suh, Y., Rines, D., Van Orsouw, N. & Vijg, J.High-speed, multicolor fluorescent two-dimensional gene scanning. Genomics. Nov 2001. https://www.sciencedirect.com/science/article/pii/S0888754301966492

Dollé, M. E. T., Snyder, W. K. & Vijg, J. Genotyping the Prop-1 mutation in Ames dwarf mice. Mechanisms of Ageing and Development. 2001 Oct. https://www.sciencedirect.com/science/article/pii/S0047637401002822

 

Martin, S. L., Hopkins, C. L., Naumer, A., Dollé, M. E. T. & Vijg, J. Mutation frequency and type during ageing in mouse seminiferous tubules. Mechanisms of Ageing and Development. 2001 Sep. https://www.sciencedirect.com/science/article/pii/S0047637401002676

 

Guo, Z., Van Remmen, H., Yang, H., Chen, X., Mele, J., Vijg, J., Epstein, C. J., Ho, Y. S. & Richardson, A. Changes in expression of antioxidant enzymes affect cell-mediated LDL oxidation and oxidized LDL-induced apoptosis in mouse aortic cells. Arteriosclerosis, Thrombosis, and Vascular Biology. 2001 Jul. https://www.ahajournals.org/doi/full/10.1161/hq0701.092092

 

Vijg, J. Opinion. Mechanisms of Ageing and Development. 2001 Feb. https://www.sciencedirect.com/science/article/pii/S0047637400002372?via%3Dihub

 

Vijg, J., Perls, T., Franceschi, C. & Van Orsouw, N. J. BRCA1 gene sequence variation in centenarians. Annals of the New York Academy of Sciences. 2001 Jan. https://nyaspubs.onlinelibrary.wiley.com/doi/full/10.1111/j.1749-6632.2001.tb05639.x

 

Sang Chul Park, C. P., Kitani, K., Yu, B. P., Ingram, D. K., Reznick, A., Goto, S., Roth, G. S., Zs.-Nagy, I., Meydani, M., Vijg, J., Harmon, D. & Stadtman, E. Perspectives in aging research in the new millennium. Annals of the New York Academy of Sciences. 2001. 

 

Eng, C., Brody, L. C., Wagner, T. M. U., Devilee, P., Vijg, J., Szabo, C., Tavtigian, S. V., Nathanson, K. L., Ostrander, E., Frank, T. S., Borg, A., Brody, L. C., Couch, F., Devilee, P., Easton, D. F., Eng, C., Frank, T. S., Goldgar, D. F., Nathanson, K. A., Neuhausen, S. & 16 others. Interpreting epidemiological research: Blinded comparison of methods used to estimate the prevalence of inherited mutations in BRCA1. Journal of Medical Genetics. 2001. https://jmg.bmj.com/content/38/12/824.full

 

Vijg, J., Giese, H. & Dollé, M. E. T. Models for stuyding genomic instability during aging. Advances in Cell Aging and Gerontology. 2001. https://www.sciencedirect.com/science/article/pii/S1566312401040287

 


2000

 

Bailey-Wilson, J., Baron, J., Cawthon, R., Christian, J. C., Corder, E. H., Franceschi, C., Kestenbaum, B., Kruglyak, L., Lauderdale, D. S., Lubitz, J., Martin, G. M., McClearn, G. E., McGue, M., Miles, T., Mineau, G., Ouellett, G., Pedersen, N. L., Preston, S. H., Page, W. F., Province, M. & 8 others. Genetic epidemiologic studies on age-specified traits. American Journal of Epidemiology. 2000 Dec 1. https://academic.oup.com/aje/article/152/11/1003/124207

 

Distinct spectra of somatic mutations accumulated with age in mouse heart and small intestine. Dollé, M. E. T., Snyder, W. K., Gossen, J. A., Lohman, P. H. M. & Vijg, J. Proceedings of the National Academy of Sciences of the United States of America. 2000 Jul 18. https://www.pnas.org/content/97/15/8403

 

Van Steeg, H., Mullenders, L. H. F. & Vijg, J. Mutagenesis and carcinogenesis in nucleotide excision repair-deficient XPA knock out mice. Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis. 2000 May 30. https://www.sciencedirect.com/science/article/pii/S0027510700000233

 

Yeh, J. J., Lunetta, K. L., Van Orsouw, N. J., Moore, F. D., Mutter, G. L., Vijg, J., Dahia, P. L. & Eng, C. Somatic mitochondrial DNA (mtDNA) mutations in papillary thyroid carcinomas and differential mtDNA sequence variants in cases with thyroid tumours. Oncogene. 2000 Apr 13. https://www.nature.com/articles/1203537

 

Vijg, J. The science of aging and the need for a mechanistic approach. Mechanisms of Ageing and Development. 2000 Feb 22.

 

Vijg, J. Somatic mutations and aging: A re-evaluation. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 2000 Jan 17. https://www.sciencedirect.com/science/article/pii/S002751079900202X

 

Schriner, S. E., Ogburn, C. E., Smith, A. C., Newcomb, T. G., Ladiges, W. C., Dollé, M. E. T., Vijg, J., Fukuchi, K. I. & Martin, G. M. Levels of dna damage are unaltered in mice overexpressing human catalase in nuclei. Free Radical Biology and Medicine. 2000 Jan. 

 

Vijg, J. 6. Somatic DNA alterations and aging. Facts, Research and Intervention in Geriatrics. 2000.

 

Dollé, M. E., Giese, H., van Steeg, H. & Vijg, J. Mutation accumulation in vivo and the importance of genome stability in aging and cancer. Results and Problems in Cell Differentiation. 2000. https://link.springer.com/chapter/10.1007/978-3-540-48003-7_9
 


1999

 

Dollé, M. E. T., Snyder, W. K., Van Orsouw, N. J. & Vijg, J. Background mutations and polymorphisms in lacZ-plasmid transgenic mice. Environmental and Molecular Mutagenesis. 1999 Oct. https://doi.org/10.1002/(SICI)1098-2280(1999)34:2/3<112::AID-EM9>3.0.CO;2-W

 

Khrapko, K., Bodyak, N., Thilly, W. G., Van Orsouw, N. J., Zhang, X., Coller, H. A., Peris, T. T., Upton, M., Vijg, J. & Wei, J. Y. Cell-by-cell scanning of whole mitochondrial genomes in aged human heart reveals a significant fraction of myocytes with clonally expanded deletions. Nucleic Acids Research. 1999 Jun 1. https://academic.oup.com/nar/article/27/11/2434/1260912

 

Dollé, M. E. T., Martus, H. J., Novak, M., Van Orsouw, N. J. & Vijg, J. Characterization of color mutants in lacZ plasmid-based transgenic mice, as detected by positive selection. Mutagenesis. 1999 May. https://academic.oup.com/mutage/article/14/3/287/1162225

 

Giese, H., Dollé, M. E. T., Hezel, A., Van Steeg, H. & Vijg, J. Accelerated accumulation of somatic mutations in mice deficient in the nucleotide excision repair gene XPA. Oncogene. 1999 Feb 4. https://www.nature.com/articles/1202404

 

Van Orsouw, N. J. & Vijg, J. Design and application of 2-D DGGE-based gene mutational scanning tests. Genetic Analysis - Biomolecular Engineering. 1999 Feb. https://www.sciencedirect.com/science/article/pii/S105038629800028X

 

Vijg, J. Genetics of aging sponsored by Cold Spring Harbor Laboratory, 2-5 April 1998. Biochimica et Biophysica Acta - Reviews on Cancer. 1999 Jan 29. 

 

Van Orsouw, N. J., Dhanda, R. K., Elhaji, Y., Narod, S. A., Li, F. P., Eng, C. & Vijg, J. A highly accurate, low cost test for BRCA1 mutations. Journal of Medical Genetics. 1999. https://jmg.bmj.com/content/36/10/747.full

 

Van Oostrom, C. T. M., Boeve, M., Van Den Berg, J. D., De Vries, A., Dollé, M. E. T., Beems, R. B., Van Kreijl, C. F., Vijg, J. & Van Steeg, H. Effect of heterozygous loss of p53 on benzo[a]pyrene-induced mutations and tumors in DNA repair-deficient XPA mice. Environmental and Molecular Mutagenesis. 1999. https://onlinelibrary.wiley.com/doi/abs/10.1002/(SICI)1098-2280(1999)34:2/3%3C124::AID-EM11%3E3.0.CO;2-F

 

Vijg, J. Profiling aging by gene arrays. Mechanisms of Ageing and Development. 1999.

 

Vijg, J. & Van Orsouw, N. J. Two-dimensional gene scanning: Exploring human genetic variability. Electrophoresis. 1999. https://onlinelibrary.wiley.com/doi/abs/10.1002/(SICI)1522-2683(19990101)20:6%3C1239::AID-ELPS1239%3E3.0.CO;2-T
 


1998

 

Van Orsouw, N. J., Zhang, X., Wei, J. Y., Johns, D. R. & Vijg, J. Mutational scanning of mitochondrial DNA by two-dimensional electrophoresis. Genomics. 1998 Aug 15. https://www.sciencedirect.com/science/article/pii/S0888754398954106?via%3Dihub

 

Rines, R. D., Van Orsouw, N. J., Sigalas, I., Li, F. P., Eng, C. & Vijg, J. Comprehensive mutational scanning of the p53 coding region by two-dimensional gene scanning. Carcinogenesis. 1998 Jun. https://academic.oup.com/carcin/article/19/6/979/2365476

 

Vijg, J. & Van Steeg, H. Transgenic assays for mutations and cancer: Current status and future perspectives. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 1998 May 25. https://www.sciencedirect.com/science/article/pii/S002751079800030X?via%3Dihub

 

Perls, T. T., Bubrick, E., Wager, C. G., Vijg, J. & Kruglyak, L. Siblings of centenarians live longer. Lancet. 1998 May 23. https://www.sciencedirect.com/science/article/pii/S0140673605611269?via%3Dihub

 

Van Orsouw, N. J., Dhanda, R. K., Rines, R. D., Smith, W. M., Sigalas, I., Eng, C. & Vijg, J. Rapid design of denaturing gradient-based two-dimensional electrophoretic gene mutational scanning tests. Nucleic Acids Research. 1998 May 15. https://academic.oup.com/nar/article/26/10/2398/1032840

 

Smith, W. M., Van Orsouw, N. J., Fox, E. A., Kolodner, R. D., Vijg, J. & Eng, C. Accurate, high-throughput "snapshot" detection of hMLH1 mutations by two-dimensional DNA electrophoresis. Genetic Testing. 1998. https://www.liebertpub.com/doi/abs/10.1089/gte.1998.2.43

 

Dhanda, R. K., Smith, W. M., Scott, C. B., Eng, C. & Vijg, J. A simple system for automated two-dimensional electrophoresis: applications to genetic testing. Genetic Testing. 1998. https://www.liebertpub.com/doi/abs/10.1089/gte.1998.2.67

 

Dabora, S. L., Sigalas, I., Hall, F., Eng, G., Vijg, J. & Kwiatkowski, D. J. Comprehensive mutation analysis of TSC1 using two-dimensional DNA electrophoresis with DGGE. Annals of Human Genetics. 1998. https://onlinelibrary.wiley.com/doi/abs/10.1046/j.1469-1809.1998.6260491.x

 

Dhanda, R. K., Van Orsouw, N. J., Sigalas, Eng, C. & Vijg, J. Critical factors in the performance and cost of two-dimensional gene scanning: RB1 as a model. BioTechniques. 1998. https://www.future-science.com/doi/10.2144/98254dt06
 


1997

 

Vijg, J., Dollé, M. E., Martus, H. J. & Boerrigter, M. E. Transgenic mouse models for studying mutations in vivo: applications in aging research. Mechanisms of Ageing and Development. 1997 Dec 30. https://www.sciencedirect.com/science/article/pii/S0047637497001073

 

Vijg, J., Dollé, M. E. T., Martus, H. J. & Boerrigter, M. E. T. I. Transgenic mouse models for studying mutations in vivo: Applications in aging research. Mechanisms of Ageing and Development. 1997 Dec. https://www.sciencedirect.com/science/article/pii/S0047637497001073?via%3Dihub

 

De Vries, A., Dollé, M. E. T., Broekhof, J. L. M., Muller, J. J. A., Kroese, E. D., Van Kreijl, C. F., Capel, P. J. A., Vijg, J. & Van Steeg, H. Induction of DNA adducts and mutations in spleen, liver and lung of XPA-deficient lacZ transgenic mice after oral treatment with benzo[a]pyrene: Correlation with tumour development. Carcinogenesis. 1997 Dec. https://doi.org/10.1093/carcin/18.12.2327

 

Marsh, D. J., Roth, S., Lunetta, K. L., Hemminki, A., Dahia, P. L. M., Sistonen, P., Zheng, Z., Caron, S., Van Orsouw, N. J., Bodmer, W. F., Cottrell, S. E., Dunlop, M. G., Eccles, D., Hodgson, S. V., Järvinen, H., Kellokumpu, I., Markie, D., Neale, K., Phillips, R., Rozen, P. & 5 others. Exclusion of PTEN and 10q22-24 as the susceptibility locus for juvenile polyposis syndrome. Cancer Research. 1997 Nov 15. http://cancerres.aacrjournals.org/content/57/22/5017.short

 

Eng, C. & Vijg, J. Genetic testing: The problems and the promise. Nature Biotechnology. 1997 May.

 

Van Orsouw, N. J., Li, D. & Vijg, J. Denaturing gradient gel electrophoresis (DGGE) increases resolution and informativity of Alu-directed inter-repeat PCR. Molecular and Cellular Probes. 1997 Apr. https://www.sciencedirect.com/science/article/pii/S0890850896900894?via%3Dihub

 

Børglum, A. D., Nyegaard, M., Kvistgaard, A. B., Mullaart, E., Uitterlinden, A. G., Vijg, J. & Kruse, T. A. Mapping of 34 minisatellite loci resolved by two-dimensional DNA typing. Cytogenetics and Cell Genetics. 1997.

 

Dollé, M. E. T., Giese, H., Hopkins, C. L., Martus, H. J., Hausdorff, J. M. & Vijg, J. Rapid accumulation of genome rearrangements in liver but not in brain of old mice. Nature Genetics. 1997. https://www.nature.com/articles/ng1297-431

 

Boerrigter, M. E. T. I. & Vijg, J. Sources of variability in mutant frequency determinations in different organs of lacZ plasmid-based transgenic mice: Experimental features and statistical analysis. Environmental and Molecular Mutagenesis. 1997. https://onlinelibrary.wiley.com/doi/abs/10.1002/%28SICI%291098-2280%281997%2929%3A3%3C221%3A%3AAID-EM1%3E3.0.CO%3B2-F

 

Romano-Spica, V. & Vijg, J. Two-dimensional DNA electrophoresis: state of the art and applications. Biotechnology Annual Review. 1997. https://www.sciencedirect.com/science/article/pii/S1387265608700280

 


1996

 

Van Orsouw, N. J., Li, D., Van Der Vlies, P., Scheffer, H., Eng, C., Buys, C. H. C. M., Li, F. P. & Vijg, J. Mutational scanning of large genes by extensive PCR multiplexing and two-dimensional electrophoresis: Application to the RB1 gene. Human Molecular Genetics. 1996 Jun. https://academic.oup.com/hmg/article/5/6/755/2568765

 

Dollé, M. E. T., Martus, H. J., Gossen, J. A., Boerrigter, M. E. T. I. & Vijg, J. Evaluation of a plasmid-based transgenic mouse model for detecting in vivo mutations. Mutagenesis. 1996 Jan. https://academic.oup.com/mutage/article/11/1/111/1168232

 

Wu, Y., Hofstra, R. M. W., Scheffer, H., Uitterlinden, A. G., Mullaart, E., Buys, C. H. C. M. & Vijg, J. Comprehensive and accurate mutation scanning of the CFTR gene by two- dimensional DNA electrophoresis. Human Mutation. 1996. 

 

Li, D. & Vijg, J. Multiplex co-amplification of 24 retinoblastoma gene exons after pre-amplification by long-distance PCR. Nucleic Acids Research. 1996. https://academic.oup.com/nar/article/24/3/538/2360000
 


1995

 

Vijg, J. Two-dimensional DNA typing - A cost-effective way of analyzing complex mixtures of DNA fragments for sequence variations. Molecular Biotechnology. 1995 Dec.

 

MULLAART, E., VERWEST, A. M., BØRGLUM, A. D., UITTERLINDEN, A. G., TEMEERMAN, JG. G., KRUSE, T. A. & Vijg, J. Two-Dimensional DNA Typing of Human Pedigrees: Spot Pattern Characterization and Segregation. Genomics. 1995 Oct. https://www.sciencedirect.com/science/article/pii/S0888754385799557

 

Boerrigter, M. E. T. I., Wei, J. Y. & Vijg, J. Induction and repair of benzo[a]pyrene-DNA adducts in C57BL/6 and BALB/c mice: association with aging and longevity. Mechanisms of Ageing and Development. 1995 Jul 28. https://www.sciencedirect.com/science/article/pii/004763749501603W

 

Xiao, S., Li, D., Corson, J. M., Vijg, J. & Fletcher, J. A. Codeletion of p15 and p16 genes in primary non-small cell lung carcinoma. Cancer Research. 1995. http://cancerres.aacrjournals.org/content/55/14/2968.short

 

Xiao, S., Li, D., Vijg, J., Sugarbaker, D. J., Corson, J. M. & Fletcher, J. A. Codeletion of p15 and p16 in primary malignant mesothelioma. Oncogene. 1995.

 

Vijg, J. Detecting individual genetic variation. Bio/Technology. 1995.

 

Boerrigter, M. E. T. I., Dollé, M. E. T., Martus, H. J., Gossen, J. A. & Vijg, J. Plasmid-based transgenic mouse model for studying in vivomutations. Nature. 1995. https://www.nature.com/articles/377657a0.pdf?origin=ppub

V

ijg, J. Somatic mutations and aging: Cause or effect? Mutation Research - DNAging Genetic Instability and Aging. 1995.

Gossen, J. A., Martus, H. J., Wei, J. Y. & Vijg, J. Spontaneous and X-ray-induced deletion mutations in a LacZ plasmid-based transgenic mouse model. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 1995. https://www.sciencedirect.com/science/article/pii/002751079500055N

 

Borglum, A. D., Mullaart, E., Kvistgaard, A. B., Uitterlinden, A. G., Vijg, J. & Kruse, T. A. Two-dimensional DNA typing as a genetic marker system in humans. Cytogenetics and Cell Genetics. 1995. https://www.karger.com/Article/Abstract/134123

 

Vijg, J. & Wei, J. Y. Understanding the biology of aging: The key to prevention and therapy. Journal of the American Geriatrics Society. 1995. https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1532-5415.1995.tb05819.x

 

Martus, H. J., Dolle, M. E. T., Gossen, J. A., Boerrigter, M. E. T. I. & Vijg, J. Use of transgenic mouse models for studying somatic mutations in aging. Mutation Research DNAging. 1995. https://www.sciencedirect.com/science/article/pii/0921873495000252
 


1994

 

Vijg, J., Wu, Y., Uitterlinden, A. & Mullaart, E. Two-dimensional DNA electrophoresis in mutation detection. Mutation Research Regular Papers. 1994 Jul 16. https://www.sciencedirect.com/science/article/pii/0027510794901554

 

Gossen, J. A., de Leeuw, W. J. F. & Vijg, J. LacZ transgenic mouse models: their application in genetic toxicology. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 1994 Jun 1. https://www.sciencedirect.com/science/article/pii/0027510794902569

 

Mientjes, E. J., van Delft, J. H. M., op't Hof, B. M., Gossen, J. A., Vijg, J., Lohman, P. H. M. & Baan, R. A. An improved selection method for λlacZ- phages based on galactose sensitivity. Transgenic Research. 1994 Jan. https://link.springer.com/article/10.1007/BF01976029


Verwest, A. M., de Leeuw, W. J. F., Molijn, A. C., Andersen, T. I., Börresen, A. L., Mullaart, E., Uitterlinden, A. G. & Vijg, J. Genome scanning of breast cancers by two-dimensional DNA typing. British Journal of Cancer. 1994 Jan. https://www.nature.com/articles/bjc199413


1993

 

Te Meerman, G. J., Mullaart, E., Van Der Meulen, M. A., Den Daas, J. H. G., Morolli, B., Uitterlinden, A. G. & Vijg, J. Linkage analysis by two-dimensional DNA typing. American Journal of Human Genetics. 1993 Dec. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1682500/

 

Boerrigter, M. E. T. I., Franceschi, C., Arrigoni-Martelli, E., Wei, J. Y. & Vijg, J. The effect of L-carnitine and acetyl-L-carnitine on the disappearance of DNA single-strand breaks in human peripheral blood lymphocytes. Carcinogenesis. 1993 Oct. https://academic.oup.com/carcin/article/14/10/2131/305795

 

Mullaart, E., de Vos, G. J., te Meerman, G. J., Uitterlinden, A. G. & Vijg, J. Parallel genome analysis by two-dimensional DNA typing. Nature. 1993 Sep 30. https://www.nature.com/articles/365469a0

 

Hovig, E., Mullaart, E., Børresen, A. L., Uitterlinden, A. G. & Vijg, J. Genome Scanning of Human Breast Carcinomas Using Micro- and Minisatellite Core Probes. Genomics. 1993 Jul. https://www.sciencedirect.com/science/article/pii/S088875438371284X

 

Gossen, J. A., De Leeuw, W. J. F., Bakker, A. Q. & Vijg, J. DNA sequence analysis of spontaneous mutations at a LacZ transgene integrated on the mouse X chromosome. Mutagenesis. 1993 May. https://academic.oup.com/mutage/article/8/3/243/1069003

 

Trommelen, G. J., Den Daas, N. H., Vijg, J. & Uitterlinden, A. G. Identity and paternity testing of cattle: application of a deoxyribonucleic acid profiling protocol. Journal of Dairy Science. 1993 May.

 

Hoorn, A. J. W., Custer, L. L., Myhr, B. C., Brusick, D., Gossen, J. & Vijg, J. Detection of chemical mutagens using muta mouse: A transgenic mouse model. Mutagenesis. 1993 Jan. https://academic.oup.com/mutage/article/8/1/7/1005090

 

Gossen, J. A. & Vijg, J. A selective system for lacZ- phage using a galactose-sensitive E. coli host. BioTechniques. 1993. 

 

Boerrigter, M. E. T. I., Yin, Y., Vijg, J. & Wei, J. Y. DNA repair in congenic mice: Possible influence of a chromosome 4 genetic region on the rate of benzo[a]pyrene-induced DNA adduct removal. Journals of Gerontology. 1993. https://academic.oup.com/geronj/article/48/1/B11/557472

 

Gossen, J. A., De Leeuw, W. J. F., Molijn, A. C. & Vijg, J. Plasmid rescue from transgenic mouse DNA using LacI repressor protein conjugated to magnetic beads. BioTechniques. 1993.

 

Vijg, J. & Gossen, J. A. Somatic mutations and cellular aging. Comparative Biochemistry and Physiology -- Part B: Biochemistry and Molecular Biology. 1993. https://www.sciencedirect.com/science/article/pii/0305049193902646

 

Gossen, J. & Vijg, J. Transgenic mice as model systems for studying gene mutations in vivo. Trends in Genetics. 1993. https://www.sciencedirect.com/science/article/pii/016895259390069T
 


1992

 

Gossen, J. A., Molijn, A. C., Douglas, G. R. & Vijg, J. Application of galactose-sensitive E.coli strains as selective hosts for LacZ plasmids. Nucleic Acids Research. 1992 Jun 25. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC312470/

 

Huppes, W., De Groot, C. J. A., Ostendorf, R. H., Bauman, J. G. J., Gossen, J. A., Smit, V., Vijg, J. & Dijkstra, C. D. Detection of migrated allogeneic oligodendrocytes throughout the central nervous system of the galactocerebrosidase-deficient twitcher mouse. Journal of Neurocytology. 1992 Feb. https://www.ncbi.nlm.nih.gov/pubmed/1348528

 

Boerrigter, M. E. T. I., Wei, J. Y. & Vijg, J. DNA repair and Alzheimer's disease. Journals of Gerontology. 1992. https://www.ncbi.nlm.nih.gov/pubmed/1430845

 

Boerrigter, M. E. T. I. & Vijg, J. Single-Strand break disappearance in quiescent and phytohaemagglutinin-stimulated human peripheral blood lymphocytes exposed to a single low dose of γradiation. International Journal of Radiation Biology. 1992. https://www.tandfonline.com/doi/abs/10.1080/09553009214550661

 

Slagboom, P. E. & Vijg, J. The dynamics of genome organization and expression during the aging process. Annals of the New York Academy of Sciences. 1992. https://nyaspubs.onlinelibrary.wiley.com/doi/abs/10.1111/j.1749-6632.1992.tb27437.x

 

Vijg, J., De Leeuw, W. J. F., Douglas, G. R. & Gossen, J. A. Transgenic mice and age-related mutations. Annals of the New York Academy of Sciences. 1992. 


1991

 

Boerrigter, M. E. T. I., Mullaart, E., Berends, F. & Vijg, J. Induction and disappearance of DNA strand breaks and/or alkalilabile sites in human lymphocytes exposed to N-ethyl-N-nitrosourea. Carcinogenesis. 1991 Jan. https://academic.oup.com/carcin/article/12/1/77/277175

 

Gossen, J. A., de Leeuw, W. J., Verwest, M. & Vijg, J. Analysis of spontaneous and induced mutation frequencies in transgenic mice using a lambda shuttle vector system. Progress in Clinical and Biological Research. 1991.

 

Boerrigter, M. E. T. I., Van Duijn, C. M., Mullaart, E., Eikelenboom, P., Van Der Togt, C. M. A., Knook, D. L., Hofman, A. & Vijg, J. Decreased DNA repair capacity in familial, but not in sporadic Alzheimer's disease. Neurobiology of Aging. 1991. https://repub.eur.nl/pub/5785/

 

Uitterlinden, A. G. & Vijg, J. Denaturing gradient gel electrophoretic analysis of minisatellite alleles. Electrophoresis. 1991. https://onlinelibrary.wiley.com/doi/abs/10.1002/elps.1150120104

 

Vijg, J., Gossen, J. A., De Leeuw, W. J. F., Mullaart, E., Slagboom, P. E. & Uitterlinden, A. G. DNA processing, aging, and cancer: The impact of new technology. Annals of the New York Academy of Sciences. 1991. 

 

Uitterlinden, A. G., Slagboom, E. P., Mullaart, E., Meulenbelt, I. & Vijg, J. Genome scanning by two-dimensional DNA typing: The use of repetitive DNA sequences for rapid mapping of genetic traits. Electrophoresis. 1991. https://onlinelibrary.wiley.com/doi/abs/10.1002/elps.1150120206

 

Uitterlinden, A. G., Mullaart, E., Morolli, B. & Vijg, J. Genome scanning of higher eukaryotes by two-dimensional DNA typing using micro- and minisatellite core probes. Methods. 1991. https://www.sciencedirect.com/science/article/pii/S1046202305801999

 

Gossen, J. A., de Leeuw, W. J. F., Verwest, A., Lohman, P. H. M. & Vijg, J. High somatic mutation frequencies in a LacZ transgene integrated on the mouse X-chromosome. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 1991. https://www.sciencedirect.com/science/article/pii/002751079190198W

 

Boerrigter, M. E. T. I. & Vijg, J. Induction and disappearance of DNA single-strand breaks in human B and T lymphocytes after exposure to ethylnitrosourea. Mutation Research-DNA Repair. 1991. https://www.sciencedirect.com/science/article/pii/092187779190017J

 

Boerrigter, M. E. T. I., Mullaart, E. & Vijg, J. Induction and disappearance of DNA strand breaks in human peripheral blood lymphocytes and fibroblasts treated with methyl methanesulfonate. Experimental Cell Research. 1991. https://www.sciencedirect.com/science/article/pii/001448279190157P

 

Slagboom, P. E., Uitterlinden, A. G. & Vijg, J. Methylation status of cKi-ras and MHC genes in rat pituitary glands during aging and tumorigenesis. Aging - Clinical and Experimental Research. 1991. https://link.springer.com/article/10.1007/BF03323991

 

Vijg, J. New methods for the detection of genetic variation. Annali dell'Istituto Superiore di Sanita. 1991. 

 

Slagboom, P. E., Mullaart, E., Droog, S. & Vijg, J. Somatic mutations and cellular aging: two-dimensional DNA typing of rat fibroblast clones. Mutation Research DNAging. 1991. https://www.sciencedirect.com/science/article/pii/0921873491900224
 

 

 

1990

 

Vijg, J. & Papaconstantinou, J. Aging and longevity genes: Strategies for identifying DNA sequences controlling life span. Journals of Gerontology. 1990. https://academic.oup.com/geronj/article/45/5/B179/651559

 

Uitterlinden, A. G. & Vijg, J. Denaturing gradient gel electrophoretic analysis of the human cHa-ras1 proto-oncogene. Applied and theoretical electrophoresis : the official journal of the International Electrophoresis Society. 1990. https://europepmc.org/abstract/med/2098100

 

Mullaart, E., Lohman, P. H. M., Berends, F. & Vijg, J. DNA damage metabolism and aging. Mutation Research DNAging. 1990. https://www.sciencedirect.com/science/article/pii/0921873490900018

 

Vijg, J. DNA sequence changes in aging: How frequent, how important?. Aging - Clinical and Experimental Research. 1990. https://link.springer.com/article/10.1007/BF03323904

 

Boerrigter, M. E. T. I., Mullaart, E., van der Schans, G. P. & Vijg, J. Illusory DNA breaks in quiescent lymphocytes?. Experimental Cell Research. 1990. https://www.sciencedirect.com/science/article/pii/001448279090269G?via%3Dihub

 

Mullaart, E., Boerrigter, M. E. T. I., Ravid, R., Swaab, D. F. & Vijg, J. Increased levels of DNA breaks in cerebral cortex of Alzheimer's disease patients. Neurobiology of Aging. 1990. https://www.sciencedirect.com/science/article/pii/0197458090905428


Vijg, J. Levensverlenging: de apotheose van de moleculaire biomedische wetenschappen?. Tijdschrift voor Gerontologie en Geriatrie. 1990 Oct. https://einstein.pure.elsevier.com/en/publications/extension-of-life-the-apotheosis-of-the-molecular-biomedical-scie

 

Slagboom, P. E., De Leeuw, W. J. F. & Vijg, J. Messenger RNA levels and methlation patterns of GAPDH and β-actin genes in rat liver, spleen and brain in relation to aging. Mechanisms of Ageing and Development. 1990 Apr 30. https://www.sciencedirect.com/science/article/pii/004763749090042E

 

Slagboom, P. E., de Leeuw, W. J. F. & Vijg, J. mRNA levels and methylation patterns of the tyrosine aminotransferase gene in aging inbred rats. FEBS Letters. 1990 Aug 20. https://febs.onlinelibrary.wiley.com/doi/abs/10.1016/0014-5793(90)81136-C

 

ijg, J. Searching for the molecular basis of aging: The need for life extension models. Aging - Clinical and Experimental Research. 1990. https://link.springer.com/content/pdf/10.1007/BF03323922.pdf

 

Mullaart, E., Boerrigter, M. E. T. I., Boer, G. J. & Vijg, J. Spontaneous DNA breaks in the rat brain during development and aging. Mutation Research DNAging. 1990. https://www.sciencedirect.com/science/article/pii/092187349090027O

 

Gossen, J. A. & Vijg, J. Transgenic mice as a model to study gene mutations: application as a short-term mutagenicity assay.. Progress in Clinical and Biological Research. 1990. https://www.ncbi.nlm.nih.gov/pubmed/2388919

 

 

1989

 

Quantitative comparison of mRNA levels in mammalian tissues: 28S ribosomal RNA level as an accurate internal control. de Leeuw, W. J. F., Slagboom, P. E. & Vijg, J. 1989 Dec 11. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC335273/

 

Uitterlinden, A. G., Slagboom, P. E., Johnson, T. E. & Vijg, J. The Caenorhabditis eleguns genome contains monomorphic minisatellites and simple sequences. Nucleic Acids Research. 1989 Dec 11. https://academic.oup.com/nar/article-abstract/17/23/9527/1076575

 

Vijg, J. Molecular gerontology needs coordination. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 1989 Mar. 

 

Mullaart, E., Buytenhek, M., Brouwer, A., Lohman, P. H. M. & Vijg, J. Genotoxic effects of intragastrically administered benzo[a] pyrene in rat liver and intestinal cells. Carcinogenesis. 1989 Feb. https://academic.oup.com/carcin/article/10/2/393/409139

 

Franceschi, C., Setlow, R. B., Sugimura, T. & Vijg, J. About an old problem, new approaches, a new section. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 1989 Mar. https://moh-it.pure.elsevier.com/en/publications/about-an-old-problem-new-approaches-a-new-section-3

 

Mullaart, E., Boerrigter, M. E. T. I., Lohman, P. H. M. & Vijg, J. Age-related induction and disappearance of carcinogen-DNA-adducts in livers of rats exposed to low levels of 2-acetylaminofluorene. Chemico-Biological Interactions. 1989. https://www.sciencedirect.com/science/article/pii/0009279789901233

 

Gille, J. J. P., Mullaart, E., Vijg, J., Leyva, A. L., Arwert, F. & Joenje, H. Chromosomal instability in an oxygen-tolerant variant of Chinese hamster ovary cells. Mutation Research DNAging. 1989. https://www.sciencedirect.com/science/article/pii/0921873489900374

 

Gille, J. J. P., van Berkel, C. G. M., Mullaart, E., Vijg, J. & Joenjie, H. Effects of lethal exposure to hyperoxia and to hydrogen peroxide on NAD(H) and ATP pools in Chinese hamster ovary cells. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 1989. https://www.sciencedirect.com/science/article/pii/0027510789902017

 

Gossen, J. A., De Leeuw, W. J. F., Tan, C. H. T., Zwarthoff, E. C., Berends, F., Lohman, P. H. M., Knook, D. L. & Vijg, J. Efficient rescue of integrated shuttle vectors from transgenic mice: A model for studying mutations in vivo. Proceedings of the National Academy of Sciences of the United States of America. 1989. https://www.pnas.org/content/86/20/7971.short

 

Slagboom, P. E. & Vijg, J. Genetic instability and aging: Theories, facts, and future perspectives. Genome. 1989. http://www.nrcresearchpress.com/doi/abs/10.1139/g89-057

 

Boerrigter, M. E. T. I., Mullaart, E., Van Der Schans, G. P. & Vijg, J. Quiescent human peripheral blood lymphocytes do not contain a sizable amount of preexistent DNA single-strand breaks. Experimental Cell Research. 1989. https://academic.oup.com/nar/article-abstract/17/23/9527/1076575

 

Mullaart, E., Roza, L., Lohman, P. H. M. & Vijg, J. The removal of UV-induced pyrimidine dimers from DNA of rat skin cells in vitro and in vivo in relation to aging. Mechanisms of Ageing and Development. 1989. https://www.sciencedirect.com/science/article/pii/0047637489900377

 

Uitterlinden, A. G., Slagboom, P. E., Knook, D. L. & Vijg, J.. Two-dimensional DNA fingerprinting of human individuals. Proceedings of the National Academy of Sciences of the United States of America. 1989. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC286994/

 

Uitterlinden, A. & Vijg, J. Two-dimensional DNA typing. Trends in Biotechnology. 1989. https://link.springer.com/article/10.1007/BF02779021

 

 

1988


Gossen, J. A. & Vijg, J. E. coli C: A convenient host strain for rescue of highly methylated DNA. Nucleic Acids Research. 1988 Oct 11. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC338716/

 

Franceschi, C., Setlow, R. B., Sugimura, T. & Vijg, J. About an old problem, new approaches, a new section. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 1988 Sep. https://moh-it.pure.elsevier.com/en/publications/about-an-old-problem-new-approaches-a-new-section-3

 

Mullaart, E., Lohman, P. H. M. & Vijg, J. Differences in pyrimidine dimer removal between rat skin cells in vitro and in vivo. Journal of Investigative Dermatology. 1988 Mar. https://www.sciencedirect.com/science/article/pii/S0022202X88912675

 

Mullaart, E., Boerrigter, M. E. T. I., Brouwer, A., Berends, F. & Vijg, J. Age-dependent accumulation of alkali-labile sites in DNA of post-mitotic but not in that of mitotic rat liver cells. 1988. https://www.sciencedirect.com/science/article/pii/0047637488900176

 

 

1987


Vijg, J. & Uitterlinden, A. G. A search for DNA alterations in the aging mammalian genome: An experimental strategy. Mechanisms of Ageing and Development. science. 1987. https://www.sciencedirect.com/science/article/pii/0047637487900534

 

Gravekamp, C., van Den Bulck, L. P., Vijg, J., van de Griend, R. J. & Bolhuis, R. L. c-myc Gene expression and interleukin-2 receptor levels in cloned human CD2+,CD3+ and CD2+,CD3- lymphocytes. Natural Immunity and Cell Growth Regulation. 1987. https://europepmc.org/abstract/med/3106791

 

Lohman, P. H. M., Vijg, J., Uitterlinden, A. G., Slagboom, P., Gossen, J. A. & Berends, F. DNA methods for detecting and analyzing mutations in vivo. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 1987. https://www.sciencedirect.com/science/article/pii/002751078790100X

 

Vijg, J. & Knook, D. L. DNA repair in relation to the aging process. Journal of the American Geriatrics Society. 1987. https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1532-5415.1987.tb01400.x

 

 

1986

 

Vijg, J., Mullaart, E., Roza, L., Baan, R. A. & Lohman, P. H. M. Immunochemical detection of DNA in alkaline sucrose gradient fractions. Journal of Immunological Methods. 1986 Jul 11. https://www.sciencedirect.com/science/article/pii/0022175986901018

 

Vijg, J., Roza, L., Mullaart, E. & Lohman, P. H. Species specificity in the induction and repair of DNA damage. Progress in Clinical and Biological Research. 1986. https://inis.iaea.org/search/search.aspx?orig_q=RN:19082787

 

Vijg, J., Mullaart, E., Berends, F., Lohman, P. H. M. & Knook, D. L. UV-induced DNA excision repair in rat fibroblasts during immortalization and terminal differentiation in vitro. Experimental Cell Research. 1986. https://www.sciencedirect.com/science/article/pii/0014482786901916

 

 

1985

 

Uitterlinden, A. G., Vijg, J., Giphart, M. J. & Knook, D. L. Variation in restriction fragment length and methylation pattern of rat MHC class I genes. Experimental and Clinical Immunogenetics. 1985. https://www.ncbi.nlm.nih.gov/pubmed/2908503

 

Vijg, J., Mullaart, E., Lohman, P. H. M. & Knook, D. L. UV-induced unscheduled DNA synthesis in fibroblasts of aging inbred rats. Mutation Research DNA Repair Reports. 1985. https://www.sciencedirect.com/science/article/pii/0167881785900112

 

 

1984

 

Vijg, J., Mullaart, E., van der Schans, G. P., Lohman, P. H. M. & Knook, D. L. Kinetics of ultraviolet induced DNA excision repair in rat and human fibroblasts. Mutation Research DNA Repair Reports. 1984. https://www.sciencedirect.com/science/article/pii/0167881784900075

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